对 6 7例隐球菌性脑膜炎进行临床分析 ,发现误诊 5 9.6 % (40 / 6 7) ,病死率为 34 .3% (2 3/ 6 7) ,治愈率 2 3.81% (16 /6 7) ,两性霉素B联合 5 -氟胞嘧啶治疗 40例 ,治愈 30 % (12 / 40 )。提示该病误诊率及病死率高 ,治愈率低 ,预后取决于早期的确诊及有效的治疗。最佳药选治疗方案为两性霉素B与 5 -氟胞嘧啶的联合方案。 Clinical analysis of 67 cases of cryptococcal meningitis showed that 59.6% (40/67) were misdiagnosed, the case fatality rate was 34.3% (23/67) and the cure rate was 2.81% (16/67) ), Amphotericin B combined with 5 - flucytosine treatment of 40 cases, cured 30% (12/40). Prompt misdiagnosis and mortality, the cure rate is low, the prognosis depends on the early diagnosis and effective treatment. The best drug treatment options for amphotericin B and 5 - fluorocytosine combination program.