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目的：通过经颅多普勒（transcranial Dopple，TCD）检查获得阿尔茨海默病（Alzheimer’s disease，AD）患者与正常研究对象的脑动脉平均血流速度，探究 AD 患者脑动脉平均血流速度的变化。方法选取2014年7月至2016年7月于本院就诊的20例 AD 患者纳入 AD 组，同时选取本院体检中心同期与 AD 组患者年龄和性别相匹配的20例正常健康人纳入对照组，通过 TCD 检查基底动脉和左、右颈内动脉的平均血流速度。采用 t 检验比较两组研究对象各血管的平均血流速度。结果 AD 组患者基底动脉和左颈内动脉平均血流速度均明显低于对照组（P ＜0.05），而右颈内动脉平均血流速度虽然低于对照组，但无显著差异（P ＞0.05）。结论 AD 患者存在中枢血流动力学降低，提示中枢低灌注引起的缺血缺氧可能是促进 AD 发生发展的危险因素。“,”Objective Transcranial Doppler (TCD) measurement was used to explore the changes of cerebral artery blood flood rate in Alzheimer’s disease (AD) patients. Method TCD measurement data was collected from 30 AD patients (AD group) and 24 matched normal subjects investigated (control group) from July 2014 to July 2016 in our hospital, t-test was used to compare the mean velocity of blood flow in basilar artery, left and right internal carotid arteries between AD group and control group. Result Compared with control group, the velocity of blood flow in basilar artery and left internal carotid artery were slower in AD group patients (P 0.05). Conclusion Slower cerebral flow in AD patients suggests that hypoperfusion and hypoxia might be involved in the pathogenesis of AD.