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目的:观察apraclonidine制剂0.5% IOPIDINE滴眼液对青光眼的降眼压作用及对青光眼患者中心视野的影响。方法:选择青光眼患者16例21眼,每眼每日点用0.5％IOPIDINE三次,连续使用3个月。用药前及用药后分别测定眼压、眼前节结构以及中心视野一次,比较用药前后眼压、眼前节结构以及视野的变化情况。结果:用药后眼压显著下降,最大下降幅度为38mmHg,最小下降幅度为3.7mmHg,眼压平均下降幅度为15.1±13.4mmHg。用药后视野较用药前视野明显的改善。用药前后眼前节结构无明显改变。结论:IOPIDINE滴眼液是一种降眼压效果较好的药物,且可改善青光眼患者的视功能。
Objective: To observe the hypotensive effect of apraclonidine 0.5% IOPIDINE eye drops on glaucoma and its influence on the central visual field of patients with glaucoma. Methods: Sixteen eyes of 16 patients with glaucoma were selected. Each eye was treated with 0.5% IOPIDINE three times daily for 3 months. Before treatment and after treatment were measured intraocular pressure, anterior segment structure and central field of vision once, before and after treatment of intraocular pressure, anterior segment structure and field of vision changes. Results: After treatment, the intraocular pressure decreased significantly, the maximum decrease was 38mmHg, the minimum decrease was 3.7mmHg, the average decrease of intraocular pressure was 15.1 ± 13.4mmHg. After treatment, the field of vision than the medication before the obvious improvement. Before and after treatment no significant changes in the anterior segment structure. Conclusion: IOPIDINE eye drops is a good antihypertensive effect of drugs, and can improve visual function in patients with glaucoma.