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目的探讨血浆置换联合其它药物治疗抗-NMDA受体脑炎的应用和临床疗效。方法 1例确诊为抗-NMDA受体脑炎的患者应用血细胞离心机进行血浆置换(2-3)次/周,共进行6次治疗。治疗前后做血常规、电解质、血浆蛋白检测。结果治疗后患者球蛋白从(56.75±55.65)g/L下降至(44.52±40.11)g/L(P<0.05);白蛋白/球蛋白比值从(1.14±0.77)升高至(1.28±0.79)(P<0.01),差异有统计学意义。且患者临床症状较血浆置换前减轻,脑脊液NMDA受体抗体阳性强度减弱。结论血浆置换治疗抗-NMDA受体脑炎有效。
Objective To investigate the application and clinical efficacy of plasma exchange combined with other drugs in the treatment of anti-NMDA receptor encephalitis. Methods One patient diagnosed as anti-NMDA receptor encephalitis was treated with blood cell centrifuge (2-3 cycles / week) for 6 times. Before and after treatment to do blood, electrolytes, plasma protein testing. Results After treatment, the globulin decreased from (56.75 ± 55.65) g / L to (44.52 ± 40.11) g / L, and the albumin / globulin ratio increased from 1.14 ± 0.77 to 1.28 ± 0.79 ) (P <0.01), the difference was statistically significant. The clinical symptoms of patients were relieved compared with that before plasma exchange, and the positive intensity of NMDA receptor antibody in cerebrospinal fluid was weakened. Conclusion Plasma exchange is effective in treating anti-NMDA receptor encephalitis.