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目的探讨补脾强力复方对胸腺切除术后MG的有效性和安全性。方法回顾性分析就诊于我院的MG并胸腺切除术患者31例,其中对照组为于外院手术者16例,手术前后根据个体情况不同分别予以(溴吡斯的明+泼尼松/甲泼尼龙/地塞米松等)治疗,治疗组(补脾强力复方组)为于我院手术者15例,治疗在前者基础之上于手术前后分别加用补脾强力复方,观察比较两组治疗前后MG临床绝对评分、临床相对记分、QMG评分。结果两组一般情况比较,差异无统计学意义;治疗后两组组内手术前后MG临床绝对评分、相对评分、QMG评分比较均存在统计学差异,表明胸腺切除术后MG症状改善情况在统计学意义;组间在MG胸腺切除术后MG临床绝对评分、相对评分、QMG评分差异有统计学意义,显示治疗组疗效更有优势。结论胸腺切除术是治疗MG的重要治疗方法,治疗组和对照组均能显著改善MG胸腺切除术后重症肌无力患者的临床症状,而治疗组(补脾强力复方组)优于单纯西药治疗胸腺切除术后MG的疗效,且无肌无力危象发生,具有更为理想的有效性和安全性。
Objective To investigate the efficacy and safety of BuBu powerful compound on MG after thymectomy. Methods A retrospective analysis of 31 patients with MG and thymectomy treated in our hospital was performed. Among them, 16 patients in the control group were treated by external hospital, and were treated according to the individual condition before and after operation (Minotrimebrine + Prednisone / Methylprednisolone Nylon / dexamethasone, etc.) treatment, the treatment group (Bupi strong compound group) for the surgery in our hospital in 15 cases, the treatment based on the former were added before and after surgery with spleen and strong compound were observed before and after treatment in both groups MG clinical absolute score, clinical relative score, QMG score. Results There was no significant difference between the two groups in general conditions. There was statistical difference in clinical absolute score, relative score and QMG score between the two groups before and after operation, indicating that the improvement of MG symptoms after thymectomy was statistically significant Significance; MG between the two groups after MG thymectomy absolute clinical score, relative score, QMG score difference was statistically significant, indicating that the treatment group more advantages. Conclusions Thymectomy is an important treatment for MG. Both the treatment group and the control group can significantly improve the clinical symptoms of patients with myasthenia gravis after MG thymectomy, while the treatment group (Bupi Qiangli Fufang) is superior to the western medicine in the treatment of thymus MG after resection of the curative effect, and no risk of myasthenic crisis, with more effective and safe.