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恶性疟原虫对氯喹、奎宁及某些抗疟药复方抗性的出现和扩散,使替代药物的研究日益受到重视。本文报道坦桑尼亚6个抗氯喹恶性疟流行区原虫对法西达(500mg磺胺多辛/25mg乙胺嘧啶)敏感性体内测定的结果。在所选6个检测区,近期内经体内及体外实验均表明存在恶性疟原虫抗氯喹虫株。测定对象为在校学生患者,其中5～8岁20名、9～14岁203名,15～17岁42名。均用法西达单次顿服治疗,剂量分别为:5～8岁1
The emergence and spread of the compound resistance of Plasmodium falciparum to chloroquine, quinine and some anti-malarial drugs make the study of alternative drugs pay more and more attention. This article reports the results of the in vivo assay of the susceptibility of 6 protozoosperchoidal anti-chloroquine-resistant malaria isolates to faxidal (500 mg sulfadoxine / 25 mg pyrimethamine) in Tanzania. In the selected six test areas, the recent in vivo and in vitro experiments have shown the presence of Plasmodium falciparum chloroquine resistant strains. Subjects for the measurement of students in school, of which 5 to 8 years old 20, 9 to 14 years old 203, 15 to 17 years old 42. All patients were treated with Xidatian Dayton, the doses were 5 to 8 years old1