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目的 探讨胃肠道恶性肿瘤及其周围边组织中c -mycmRNA表达与手术切缘的安全性关系。方法 用RT -PCR方法检测了 12例胃癌和 16例肠癌标本肿瘤中心及周边组织中c-mycmRNA的表达。结果 肿瘤的各种分型与各个分期c -mycmRNA的表达无显著性差异。肿瘤周边组织中 ,距肿瘤边缘 4cm处c -mycmRNA表达率显著下降 (P <0 .0 5 ) ,距肿瘤边缘 5cm以远表达率为 0。结论 根据c -mycmRNA表达 ,距肿瘤边缘 5cm处可定为肿瘤较安全的切缘
Objective To investigate the relationship between c-myc mRNA expression and surgical margins in gastrointestinal cancer and its peripheral tissues. Methods The expression of c-myc mRNA in 12 cases of gastric cancer and 16 cases of colorectal cancer was detected by RT-PCR. Results There was no significant difference in the expression of c-myc mRNA among various tumor types and stages. The expression of c-mycmRNA at 4cm away from the edge of the tumor was significantly decreased (P <0.05) in the surrounding tissues and 0 at the distance of 5cm from the edge of the tumor. Conclusion According to the expression of c-mycmRNA, 5cm away from the edge of tumor can be regarded as the safer margin of tumor