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目的:评价源自丈夫、工作场所以及生命早期家庭成员的环境烟草烟雾暴露与中国妇女全死因、恶性肿瘤或心血管疾病死亡率的关系。设计:中国上海正在进行的前瞻性队列研究。参加人员:72829名从不吸烟妇女中有65180人提供了其丈夫的吸烟资料,有66520人提供了源自工作场所和生命早期家庭成员的烟草烟雾暴露资料。主要的评价结果指标:全死因死亡率以及恶性肿瘤、心血管疾病死亡专率。按暴露状况分层的累积死亡率以及风险比。结果:源自丈夫的烟草烟雾暴露(主要是现时暴露)与全死因死亡率增加有显著联系,风险比(HR)为1．15,95％可信区间为1．01～1．31,与心血管疾病死亡率增加也有联系(1．37,1．06～1．78)。源自工作场所的烟草烟雾暴露与恶性肿瘤死亡率增加有联系(1．19,0．94～1．50),特别是肺癌(1．79,1．09～2．93)。生命早期暴露与心血管疾病死亡率增加有联系(1．26,0．94～1．69)。结论:在中国妇女中环境烟草烟雾暴露与全死因死亡率以及肺癌和心血管疾病死亡率的中等度增加有关。
Objective: To evaluate the relationship between environmental tobacco smoke exposure originating from husbands, the workplace and early members of life, and the death rate of all causes of death, cancer or cardiovascular disease in Chinese women. Design: An ongoing prospective cohort study in Shanghai, China. Participants: Of the 72,829 never-smuggling women, 65,180 provided smoking information to their husbands and 66,520 provided tobacco smoke exposure information from the workplace and early members of the family. The main outcome of the evaluation indicators: all-cause mortality and cancer, cardiovascular disease death rate. Cumulative mortality stratified by exposure and risk ratio. Results: Tobacco smoke exposure (mainly present exposure) from husbands was significantly associated with an increase in all-cause mortality with a hazard ratio (HR) of 1.15 and a 95% confidence interval of 1.01 to 1.31, Cardiovascular mortality also increased (1.37, 1.06 ~ 1.78). Exposure to tobacco smoke from the workplace was associated with an increased mortality from malignancies (1.19, 0.94 to 1.50), especially lung cancer (1.79, 1.09 to 2.93). Early exposure to life is associated with an increased mortality from cardiovascular disease (1.26, 0.94 to 1.69). Conclusion: Environmental tobacco smoke exposure among Chinese women is associated with a moderate increase in all-cause mortality and lung cancer and cardiovascular disease mortality.