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目的 :探索缬草提取物对胆囊结石的治疗作用与肝、胆囊组织内肿瘤坏死因子 (TNF)及白细胞介素 1(IL 1)水平的关系。方法 :大耳白种家兔 ,手术植入胆固醇结石。实验组喂缬草提取物 ,对照组灌喂等容、等渗蒸馏水溶液。8周后 ,手术取出胆囊结石称重 ,测量肝脏、胆囊组织中TNF、IL 1水平 ,胆囊壁做组织学检查。结果 :实验组结石平均重量较对照组明显为轻 (P <0 .0 1) ;结石消失率达 75 %。实验组肝组织内TNF、IL 1水平与对照组比较无明显差异 (P >0 .0 5 )。胆囊组织内TNF、IL 1水平明显低于对照组 (P <0 .0 1)。对照组的胆囊组织呈明显炎性改变 ,实验组的胆囊组织则基本正常。结论 :缬草提取物对胆囊胆固醇结石有明显的治疗作用 ,其作用与胆囊组织内TNF及IL 1水平有关。
Objective : To explore the relationship between the therapeutic effect of Valeriana extract on gallstones and the levels of tumor necrosis factor (TNF) and interleukin-1 (IL 1) in liver and gallbladder tissues. Methods : Large white rabbits were implanted with cholesterol stones. The experimental group was fed with the extract of Radix Paeoniae Rubra, and the control group was fed with isotonic and isotonic distilled water solution. After 8 weeks, gallbladder stones were removed by surgery. The levels of TNF and IL 1 in the liver and gallbladder tissues were measured, and the gallbladder wall was examined for histology. Results: The average weight of stones in the experimental group was significantly lighter than that in the control group (P < 0.01); the disappearance of stones was 75%. The levels of TNF and IL 1 in liver tissue of the experimental group were not significantly different from those in the control group (P > 0.05). The level of TNF and IL 1 in gallbladder tissue was significantly lower than that in the control group (P < 0.01). The gallbladder tissue of the control group showed significant inflammatory changes, while the gallbladder tissue of the experimental group was basically normal. Conclusion: Herba extract has obvious therapeutic effect on cholecystolithiasis, and its effect is related to the levels of TNF and IL 1 in gallbladder tissue.