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目的 初步探讨复发性口腔溃疡 (recurrentoralulcer ,ROU)与消化性溃疡 (pepticulcer,PU)在发病上有无关联。方法 通过ROU与PU患者口腔中的幽门螺杆菌 (helicobacterpylori,Hp)与胃粘膜Hp的聚合酶链反应 (polymerasechainreaction ,PCR)检测、免疫荧光染色和细菌培养与鉴定 ,对口腔与胃Hp进行比较。 结果 ROU或 /和PU患者口腔粘膜与胃粘膜Hp阳性率均显著高于对照组 (P <0 .0 1)且口腔中Hp的形态、生化特性、培养条件和免疫学特性均与胃粘膜Hp相似。 结论 ROU的发病机制可能和PU相似 ,二者可能有着共同的致病菌—Hp。
Objective To investigate the relationship between recurrent oral ulcer (ROU) and peptic ulcer (PU) in the pathogenesis. Methods The oral cavity and stomach Hp were compared by PCR, immunofluorescent staining, bacterial culture and identification of helicobacter pylori (Hp) and gastric mucosal Hp in the oral cavity of ROU and PU patients. Results The positive rates of Hp in oral mucosa and gastric mucosa in patients with ROU or PU were significantly higher than those in control (P <0.01). The morphology, biochemical characteristics, culture conditions and immunological characteristics of Hp in oral cavity were correlated with Hp similar. Conclusion The pathogenesis of ROU may be similar to that of PU, both of which may have a common pathogen, Hp.