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近几年的研究表明,炎症反应是卒中后继发性损害的机制之一。急性卒中后缺血灶内及其周围存在明显的炎症细胞浸润和细胞因子表达增加,同时外周血白细胞、C-反应蛋白和各种细胞因子,如肿瘤坏死因子-α、白细胞介素-1和白细胞介素-6等水平增高。卒中并发的全身炎症反应综合征是导致多器官功能障碍综合征的主要发病基础。细胞因子的失控性释放在卒中并发全身炎症反应综合征向多器官功能障碍综合征的转化过程中起关键作用。
In recent years, studies have shown that inflammation is one of the mechanisms of secondary damage after stroke. Inflammatory cell infiltration and cytokine expression were significantly increased in and around the ischemic foci after acute stroke, and peripheral blood leukocytes, C-reactive protein and various cytokines, such as tumor necrosis factor-alpha, interleukin-1 and Interleukin-6 and other levels increased. Stroke complicated by systemic inflammatory response syndrome is the main pathogenesis of multiple organ dysfunction syndrome. The uncontrolled release of cytokines plays a key role in the progression of stroke complicated with systemic inflammatory response syndromes to multiple organ dysfunction syndrome.