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目的：探讨醒脑静注射液对急性脑梗死炎症反应的影响。方法：４０例急性期脑梗死患者，随机分为２组。对照组２０例用常规方法治疗；醒脑静组２０例在常规方法治疗的基础上加用醒脑静注射液治疗。观察患者病程第３、１０、１５日外周血单核细胞（ＰＢＭＣ）ＣＤ５４分子表达情况，并与２０例健康组作比较，同时观察临床疗效。结果：患者第３日ＰＢＭＣＣＤ＋５４分子处于高水平表达状态（与健康组比较，Ｐ＜０．００１）；第１０日时，醒脑静组降至健康组水平（Ｐ＞０．０５），而对照组仍显著高于健康组（Ｐ＜０．００１），至第１５日时才达健康组水平（Ｐ＞０．０５）；且醒脑静组愈显率６５．０％，显著高于对照组３０．０％（χ２＝４．９１，Ｐ＜０．０５）。结论：醒脑静注射液对急性脑梗死炎症反应具有抑制作用，治疗脑梗死患者有效。
Objective: To investigate the effect of Xingnaojing injection on the inflammatory response in acute cerebral infarction. Methods: Forty patients with acute cerebral infarction were randomly divided into two groups. Control group of 20 patients treated by conventional methods; Xingnaojing 20 patients on the basis of conventional treatment plus Xingnaojing injection. The expression of CD54 on peripheral blood mononuclear cells (PBMC) on the 3rd, 10th, and 15th of the course of the disease was observed and compared with that of 20 healthy subjects. The clinical efficacy was also observed. Results: On the third day, the level of PBMCCD + 54 in PBMC was high level (P <0.001 compared with healthy group). On the 10th day, Xingnaojing group was decreased to healthy level (P> 0.05) (P <0.001), and reached the level of healthy group on the 15th day (P> 0.05). The effective rate of Xingnaojing group was 65.0%, which was significantly higher than that of the control group Group 30.0% (χ2 = 4.91, P <0.05). Conclusion: Xingnaojing Injection can inhibit the inflammatory response of acute cerebral infarction and is effective in treating patients with cerebral infarction.