论文部分内容阅读
1.本文叙述自邻氨基-对硝基乙苯开始分别经过九步或八步反应,合成α-二氯乙酰胺基-β-羟基-邻羟基对硝基苯丙酮(Ⅲ)和α-二氯乙酰胺基-β-羟基-邻甲氧基对硝基苯丙酮(Ⅳ),以及一些有关的化合物。 2.硝基化合物Ⅲ及Ⅳ均可以低亚硫酸钠还原成相应的氨基化合物,α-二氯乙酰胺基-β-羟基-邻羟基-对氨基苯丙酮(Ⅴ)和α-二氯乙酰胺基-β-羟基-邻甲氧基-对氨基苯丙酮(Ⅵ)。 3.曾试验邻羟基-对硝基苯甲醛与对硝基苯甲醛,及邻羟基-对硝基苯乙酮与邻甲氧基对硝基苯乙酮等两对化合物的抗菌效力。结果凡有氢键钳合结构的化合物均有较强的抗菌作用。 4.曾试验化合物Ⅲ,Ⅳ,Ⅴ,Ⅵ及其相应的去羟甲基化合物ⅩⅩ,ⅩⅪ,ⅩⅩⅧ和ⅩⅩⅨ对金色葡萄球菌,枯草杆菌,大肠杆菌和副伤寒菌B型的抑制作用。在此等化合物中(除去Ⅴ),凡有酚基与羰基形成钳合结构的化合物均有比较强的抗菌作用。化合物Ⅲ对金色葡萄球菌的抑制效力接近于氯霉素,但对革兰氏阴性菌的效力低于氯霉素;这种不一致的现象可能是Ⅲ的抗菌作用机理与氯霉素不同。
1. This article describes the synthesis of α-dichloroacetamido-β-hydroxy-o-hydroxy p-nitropropanone (Ⅲ) and α-bis Chloroacetamido-β-hydroxy-o-methoxy-p-nitropropanone (IV), and some related compounds. 2. Nitro compounds III and IV can be reduced to the corresponding amino compounds with low sodium sulfite, α-dichloroacetamido-β-hydroxy-o-hydroxy-p-aminopropiophenone (Ⅴ) and α-dichloroacetamido- β-Hydroxy-o-methoxy-p-aminopropiophenone (Ⅵ). 3. Have tested o-hydroxy-p-nitrobenzaldehyde and p-nitrobenzaldehyde, and o-hydroxy - p-nitroacetophenone and o-methoxy p-nitro-acetophenone and other two antimicrobial efficacy. Results Where the hydrogen bonding structure of the compounds have a strong antibacterial effect. 4. Inhibition of Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Paratyphoid B has been tested for compounds III, IV, V, VI and their corresponding methylolated compounds XX, XXI, XXVIII and XXIX. Among these compounds (excluding Ⅴ), all the compounds which have the phenolic group and the carbonyl group to form the clamped structure have relatively strong antibacterial activity. The inhibitory effect of compound Ⅲ on S. aureus was similar to that of chloramphenicol, but its effect on gram-negative bacteria was lower than that of chloramphenicol. This inconsistent phenomenon may be that the antibacterial mechanism of Ⅲ is different from that of chloramphenicol.