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目的:探讨了急性脑梗死(ACI)患者治疗前后血清Hcy、P选择素和IGF-Ⅰ水平的变化及临床意义。方法:应用放射免疫分析、免疫化学法和酶联法对32例ACI患者进行了治疗前后血清Hcy、P选择素和IGF-Ⅰ检测,并与35名正常健康人作比较。结果:ACI患者在治疗前血清Hcy、P选择素水平非常显著地高于正常人组(P<0.01),而血清IGF-Ⅰ水平又非常显著地低于正常人组(P<0.01),经治疗1个月后则与正常人组比较无显著性差异(P>0.05)。血清IGF-Ⅰ水平与Hcy、P选择素水平呈显著负相关(r=-0.4125、-0.3785,P<0.01)。结论:ACI患者血清Hcy、P选择素水平的升高和IGF-Ⅰ水平的降低,与患者疾病的严重程度密切相关,可作为ACI的发生、发展的敏感指标。
Objective: To investigate the changes and clinical significance of serum Hcy, P-selectin and IGF-Ⅰ levels in patients with acute cerebral infarction (ACI) before and after treatment. Methods: Serum levels of Hcy, P-selectin and IGF-Ⅰ were measured in 32 patients with ACI before and after treatment with radioimmunoassay, immunochemistry and enzyme-linked immunosorbent assay (ELISA), and compared with 35 healthy controls. Results: Before treatment, the levels of Hcy and P-selectin in patients with ACI were significantly higher than those in normal controls (P <0.01), while the levels of serum IGF-Ⅰ were significantly lower than those in normal controls (P <0.01) After 1 month of treatment, there was no significant difference compared with normal group (P> 0.05). There was a significant negative correlation between serum IGF-Ⅰ level and Hcy and P-selectin levels (r = -0.4125, -0.3785, P <0.01). CONCLUSION: Elevated serum levels of Hcy, P-selectin and IGF-I levels in patients with ACI are closely related to the severity of the disease and can be used as sensitive indicators for the occurrence and development of ACI.