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本文报告了对１０例接受术中放疗的肺癌患者术前及术后血清中总超氧化物歧化酶（ＳＯＤ）活性和丙二醛（ＭＤＡ）含量变化的动态观察结果，揭示术中放疗后早期ＳＯＤ活性和ＭＤＡ含量均迅速明显增高，术后４ｈ形成高峰。ＳＯＤ活性术后２４ｈ即降至低于术前水平，呈氧化应激表现，术后ｄ３活性最低，术后１周仍未能恢复正常。ＭＤＡ含量从高峰处随时间延长而缓慢降低，但术后１周仍较术前含量稍高。观察结果表明，肺癌术中放疗时局部照射同样可以引起全身性的自由基损伤，血清中ＳＯＤ活性和ＭＤＡ含量变化可以作为观察损伤的指标。
This article reports the dynamic observation of preoperative and postoperative serum total superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels in 10 lung cancer patients undergoing intraoperative radiotherapy, revealing early postoperative radiotherapy. SOD activity and MDA content increased rapidly and peaked at 4 h after operation. SOD activity decreased to a level below preoperative level 24 hours after surgery and showed oxidative stress. The activity of d3 was the lowest after operation, and it failed to return to normal after 1 week. The MDA content slowly decreased with time from the peak, but it was still slightly higher than the preoperative one week after surgery. The observational results show that local radiation during lung cancer surgery can also cause systemic free radical damage, and changes in serum SOD activity and MDA content can be used as indicators for the observation of injury.