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新生儿狼疮综合征是由于母亲的自身抗体通过胎盘而造成的罕见的新生儿疾病。其发病机制至今部分未明,且临床表现多样。我们报道的是具有不同临床表现的患有新生儿狼疮综合征的兄妹患儿。1例表现为先天性心脏传导阻滞,另1例表现为肝脏及血液系统病变。由于患病母亲怀孕的高危险性,兄妹患者并不多见。临床表现的不同也许可解释为因为兄妹间Anti-Ro自身抗体的特异性不同。我们还结合最近的文献就该病例进行了讨论并试图解释其发病机制。
Neonatal lupus syndrome is a rare neonatal disease caused by the mother’s autoantibodies passing through the placenta. Its pathogenesis is still unknown, and the clinical manifestations are diverse. We report that siblings with neonatal lupus syndrome have different clinical manifestations. One case showed congenital heart block and the other showed liver and blood system diseases. Due to the high risk of getting pregnant mothers, sibling patients are rare. The difference in clinical manifestations may be explained by the different specificity of anti-Ro autoantibodies between siblings. We have also discussed this case in the light of recent literature and attempted to explain its pathogenesis.