应用高亲和力的特异性单克隆抗体救治豚鼠重度地高辛中毒,成功率84.9％。当用单克隆抗体消除地高辛对豚鼠离体心房的正性肌力作用后,再给予毒毛旋花子甙K或G,仍表现明确的正性肌力效应。结果表明,高度特异、质地均一、来源无限的单克隆抗体,是一种有希望的洋地黄中毒特效解救剂。 High-affinity specific monoclonal antibodies were used to treat severe digoxin poisoning in guinea pigs with a success rate of 84.9%. When the positive inotropic effects of digoxin on isolated guinea pig atria were eliminated with monoclonal antibodies, the virulence of virgin toxins, K or G, still showed a clear positive inotropic effect. The results showed that a monoclonal antibody with high specificity, uniform texture, and unlimited source is a promising digital remedy for digitalis poisoning.