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①目的探讨中央杏仁核内神经降压素（ＮＴ）的胃粘膜保护作用与前列腺素（ＰＧＳ）的关系。②方法双侧中央杏仁核内注射微量神经降压素，肌肉注射前列腺素合成阻断剂，放射免疫分析测定胃粘膜内前列腺素Ｅ２（ＰＧＥ２）的含量。③结果肌肉分别注射消炎痛和阿斯匹林均能拮抗ＮＴ的胃粘膜保护作用（ｔ＝５．２１６～１２．３３５，Ｐ均＜０．０１），双侧中央杏仁核内注射保护剂量的ＮＴ能翻转水浸加束缚（ＣＷＲ）引起的胃粘膜ＰＧＥ２含量的降低（ｔ＝２．２６１～３．４１５，Ｐ均＜０．０５）。④结论中央杏仁核内ＮＴ的胃粘膜保护作用可能是通过ＰＧＳ为中介的
①Objective To investigate the relationship between the protective effects of neurotensin (NT) on gastric mucosa and prostaglandin (PGS) in the central amygdala. ② Methods A small amount of neurotensin was injected into the bilateral central amygdala and the prostaglandin synthesis blocker was injected intramuscularly. The contents of prostaglandin E2 (PGE2) in gastric mucosa were measured by radioimmunoassay. ③ Results Both intramuscular injection of indomethacin and aspirin could antagonize the protective effects of NT on gastric mucosa (t = 5.216 ~ 12.335, P <0.01). The protective doses NT could reverse the decrease of PGE2 in gastric mucosa caused by water immersion and restraint (t = 2.261 ~ 3.415, P <0.05). ④ Conclusion The gastric mucosal protective effect of NT in the central amygdala may be mediated by PGS