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目的探讨溃疡性结肠炎(UC)的临床特征及药物治疗效果。方法回顾性分析我院2007年1月至2009年12月收治95例UC患者的临床特征,给予水杨酸柳氮磺胺吡啶、强的松、甲硝唑、微生态制剂等药物联合治疗。结果总有效率为92.63%,完全缓解64例(67.37%),有效24例(25.26%)。治疗过程中不良反应发生率为17.89%,主要不良反应为恶心、纳差、胃烧灼感、腹胀、头痛,不良反应均较轻。结论 UC有较明显的临床特征,结肠镜检查及病理活检有助于确诊本病,水杨酸柳氮磺胺吡啶、强的松、甲硝唑、微生态制剂等药物联合规范治疗可以提高临床缓解率。
Objective To investigate the clinical characteristics and therapeutic effect of ulcerative colitis (UC). Methods The clinical features of 95 patients with UC treated in our hospital from January 2007 to December 2009 were retrospectively analyzed. Salicylate sulfasalazine, prednisone, metronidazole, probiotics and other drugs were given. Results The total effective rate was 92.63%, complete remission in 64 cases (67.37%), effective in 24 cases (25.26%). The incidence of adverse reactions during treatment was 17.89%. The main adverse reactions were nausea, anorexia, stomach burning sensation, abdominal distension, headache and mild side effects. Conclusion UC has obvious clinical features, colonoscopy and biopsy can help confirm the disease, salicylate sulfasalazine, prednisone, metronidazole, probiotics and other drugs combined with standardized treatment can improve clinical response rate.