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建立了一种恒温高压氧药物稳定性加速试验方法,用这种方法可在较短的时间内求得药物氧化反应的动力学参数.以10%维生素C溶液为例,维生素C在有氧和无氧条件下均可降解,总的降解速率常数kt由两部分构成:kt=kan+kae,kan为无氧降解速率常数,可表达为kan=Aan?exp(-Ea,an/RT);kae为有氧降解速率常数,可表达为kae=Aae?exp(-Ea,ae/RT)?pO2.
Established a constant temperature and hyperbaric oxygen drug stability accelerated test method, using this method can be obtained in a short period of time the kinetic parameters of drug oxidation reaction with 10% vitamin C solution, for example, vitamin C in aerobic and Anaerobic conditions can be degraded, the total degradation rate constant kt consists of two parts: kt = kan + kae, kan anaerobic degradation rate constant can be expressed as kan = Aan? Exp (-Ea, an / RT); kae is a constant rate of aerobic degradation and can be expressed as kae = Aae? exp (-Ea, ae / RT)? pO2.