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目的:观察川芎嗪(TMP)对新生儿缺氧缺血性脑病(HIE)的治疗作用。方法:将45例HIE患儿随机分为治疗组25例,对照组20例,另选10例健康儿为健康组,对三组患儿治疗前后一氧化氮、丙二醛、神经元特异性烯醇化酶、血钙、新生儿神经行为量表评分变化进行比较分析。结果:入院1～2d治疗组与对照组血钙无明显差异(P>0.05),且均低于健康组(P<0.05);10～11d后治疗组上升明显高于对照组(P<0.05)。血浆一氧化氮、丙二醛、神经元特异性烯醇化酶、新生儿神经行为量表评分治疗组与对照组比较差异显著(P<0.05)。结论:TMP对HIE有显著的治疗作用,值得临床推广应用。
Objective: To observe the therapeutic effect of ligustrazine (TMP) on neonatal hypoxic-ischemic encephalopathy (HIE). Methods: Forty-five children with HIE were randomly divided into treatment group (n = 25), control group (n = 20) and healthy control group (n = 10). The levels of nitric oxide, malondialdehyde Enolase, serum calcium and neonatal neurobehavioral scores were compared. Results: There was no significant difference in serum calcium between the two groups (P> 0.05), and both of them were lower than those of the healthy group (P <0.05) ). Plasma nitric oxide, malondialdehyde, neuron-specific enolase and neonatal neurobehavioral scores were significantly different between the treatment group and the control group (P <0.05). Conclusion: TMP has a significant therapeutic effect on HIE, worthy of clinical application.