论文部分内容阅读
目的探讨Cys-C在以动脉粥样硬化为基础病变的冠心病和脑梗死患者水平的变化,以及与两者发病的相关性。方法选取本院2013年10月-2014年9月住院的冠心病患者91例(B组)以及脑梗死患者122例(C组)作为研究对象,并选取同期102例健康体检者作为对照组(A组),回顾性分析Cys-C、BMG、CREA、BUN、UA等指标。结果13组间比较Cys-C、BMG、CREA差异有统计学意义(P<0.01);2B组、C组2组比较,血清Cys-C水平差异无统计学意义(P>0.05),但与A组比较差异均有统计学意义(P<0.01);3在总体与B、C组的相关分析中,均显示Cys-C与BMG、CREA、UA呈正相关,且与BMG相关性最大,与UA相关性最小;4回归分析显示,血清Cys-C升高是冠心病和脑梗死的危险因素。结论冠心病与脑梗死患者血清Cys-C水平均明显高于对照组,可以利用血清Cys-C水平作为两者发病的前期预防性诊断,除了利用血清Cys-C监测肾功能之外,还可以间接提示冠心病与脑梗死的发病。
Objective To investigate the changes of Cys-C levels in patients with coronary artery disease and cerebral infarction based on atherosclerosis and the correlation between Cys-C and the pathogenesis of both. Methods 91 patients with coronary heart disease (group B) and 122 patients with cerebral infarction (group C) hospitalized from October 2013 to September 2014 in our hospital were selected as subjects and 102 healthy subjects were selected as control group A group), Cys-C, BMG, CREA, BUN, UA and other indicators were retrospectively analyzed. Results There were significant differences in Cys-C, BMG and CREA among the 13 groups (P <0.01). There was no significant difference in serum Cys-C between the two groups (P> 0.05) There was significant difference between group A and group B (P <0.01) .3 In the correlation analysis between group B and group C, Cys-C was positively correlated with BMG, CREA and UA, and had the highest correlation with BMG. UA correlation was the smallest; 4 regression analysis showed that elevated serum Cys-C is a risk factor for coronary heart disease and cerebral infarction. Conclusions Serum levels of Cys-C in patients with coronary heart disease and cerebral infarction were significantly higher than those in the control group, and Cys-C level in serum could be used as a prophylactic diagnosis of both. In addition to using serum Cys-C to monitor renal function, Indirectly prompted the incidence of coronary heart disease and cerebral infarction.