The Cretaceous system of the Kuqa depression is a regional scale (second order) depositional sequence defined by parallel unconformities or minor angular unconformities. It can be divided into four third-order sequence sets, eleven third-order sequences and tens of fourth- and fifth-order sequences. It consists generally of a regional depositional cycle from transgres-sion to regression and is composed of three sets of facies associations: alluvial-fluvial, braided river-deltaic and lacustrine-deltaic facies associations. They represent the lowstand, transgres-sive and highstand facies tracts within the second-order sequence. The tectonic subsidence curve reconstructed by backstripping technique revealed that the Cretaceous Kuqa depression underwent a subsidence history from early accelerated subsidence, middle rapid subsidence and final slower subsidence phases during the Cretaceous time, with the correspondent tectonic subsidence rates being 3035 m/Ma, 4045 m/Ma and 510 m/Ma obtained from northern foredeep. This is likely attributed to the foreland dynamic process from early thrust flexural sub-sidence to late stress relaxation and erosion rebound uplift. The entire sedimentary history and the development of the three facies tracts are a response to the basin subsidence process. The slower subsidence foreland gentle slope was a favorable setting for the formation of braided flu-vial deltaic systems during the late period of the Cretaceous, which comprise the important sandstone reservoirs in the depression. Sediment records of impermanent marine transgression were discovered in the Cretaceous and the major marine horizons are correctable to the high-stands of the global sea level during the period. The Cretaceous system of the Kuqa depression is a regional scale (second order) depositional sequence defined by parallel unconformities or minor angular unconformities. It can be divided into four third-order sequence sets, eleven third-order sequences and tens of fourth- and fifth It consists generally of a regional depositional cycle from transgres-sion to regression and is composed of three sets of facies associations: alluvial-fluvial, braided river-deltaic and lacustrine-deltaic facies associations. They represent the lowstand, transgres- sive and highstand facies tracts within the second-order sequence. The tectonic subsidence curve reconstructed by backstripping technique revealed that the Cretaceous Kuqa depression underwent a subsidence history from early accelerated subsidence, middle rapid subsidence and final least subsidence phases during the Cretaceous time, with the correspondent tectonic subsidence rates being 3035 m / Ma, 4045 m / Ma and 510 m / Ma obtained from northern foredeep. This is likely attributed to the foreland dynamic process from early thrust flexural sub-sidence to late stress relaxation and erosion rebound uplift. The entire sedimentary history and the development of the three facies tracts are a response to the basin subsidence process. The slower subsidence foreland gentle slope was a favorable setting for the formation of braided flu-vial deltaic systems during the late period of the Cretaceous, which comprise the important sandstone reservoirs in the depression. Sediment records of impermanent marine transgression were discovered in the Cretaceous and the major marine horizons are correctable to the high-stands of the global sea level during the period.