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目的 :探讨肺癌发生发展过程中cJun、cFos表达水平。方法 :收集 42例人肺癌标本 ,其中 10例可观察到肺癌癌前病变组织 ,运用免疫组织化学的方法 ,研究cJun、cFos在上述组织中的表达水平。结果 :42例肺癌组织中cJun、cFos的阳性表达率分别为 83.2 %和 5 9.5 % ,其中鳞癌为 88.0 %和 5 6 .0 % ,腺癌为 6 9.2 %和 5 3.8% ,小细胞肺癌均为 10 0 .0 %。正常肺组织cJun、cFos表达阴性。在 4例癌前组织中 ,cJun表达为 75 % ;9例癌前病变组织中 ,cFos表达为 77.8%。结论 :在肺癌组织中 ,有cJun、cFos的高表达 ,同时 ,cJun的表达可能介导肺癌的促癌过程
Objective: To investigate the expression of cJun and cFos during the development of lung cancer. Methods: Forty-two human lung cancer specimens were collected. Among them, 10 cases of precancerous lesions were observed. Immunohistochemical methods were used to study the expression of cJun and cFos in these tissues. Results: The positive rates of cJun and cFos in 42 cases of lung cancer were 83.2% and 59.5 % respectively, of which squamous cell carcinoma was 88.0 % and 56.0%, adenocarcinoma was 69.2 % and 5 3.8%, small cell lung cancer. All are 10 0 .0%. Normal lung tissue cJun, cFos expression was negative. In 4 precancerous tissues, cJun was expressed in 75%; in 9 precancerous lesions, cFos was expressed in 77.8%. Conclusion : In lung cancer, there is high expression of cJun and cFos. At the same time, cJun expression may mediate the carcinogenesis of lung cancer.