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目的评价血清同型半胱氨酸(Hcy)在消化系统肿瘤诊断中的临床价值。方法收集160例消化系统肿瘤患者作为肿瘤组,另选取同时期的50例健康体检正常人群作为对照组。对2组人员抽取空腹静脉血,进行Hcy检测。最后绘制受试者工作特征曲线(ROC),进行相关分析。结果 160例肿瘤组患者的血清Hcy为(18.26±7.07)μmol/L;50例对照组的血清Hcy为(10.29±3.69)μmol/L,肿瘤组与对照组的血清Hcy比较,差异有统计学意义(t=10.494,P=0.000)。肿瘤组的高Hcy血症发生率也明显高于对照组(χ~2=33.107,P=0.000)。另外,肿瘤患者男性的Hcy值显著高于女性(t=5.192,P=0.000)。肿瘤患者ROC曲线的AUC为0.839,95%CI为0.760~0.918,P=0.000,最佳临界值为12.71μmol/L,灵敏度为73.80%,特异度为88.00%。其中肝癌组的AUC为0.919,灵敏度为85.00%,特异度为88.00%。结论消化道肿瘤患者血清Hcy升高明显,将Hcy作为肿瘤标志物用于消化道肿瘤的诊断,特别是肝癌的诊断具有一定的临床价值。
Objective To evaluate the clinical value of serum homocysteine (Hcy) in the diagnosis of digestive system tumors. Methods Totally 160 patients with digestive system tumors were selected as the tumor group. Another 50 healthy people at the same period were selected as the control group. Fasting venous blood was drawn from both groups and Hcy was tested. Finally, the receiver operating characteristic curve (ROC), for correlation analysis. Results Serum Hcy was (18.26 ± 7.07) μmol / L in 160 cases of tumor group, serum Hcy was (10.29 ± 3.69) μmol / L in 50 cases of control group, serum Hcy of tumor group was significantly higher than that of control group Significance (t = 10.494, P = 0.000). The incidence of hyperhomocysteinemia in the tumor group was also significantly higher than that in the control group (χ ~ 2 = 33.107, P = 0.000). In addition, the Hcy value was significantly higher in men with cancer than in women (t = 5.192, P = 0.000). The ROC curve of tumor patients had AUC of 0.839, 95% CI of 0.760-0.918, P = 0.000, the best cutoff value of 12.71μmol / L, the sensitivity of 73.80% and the specificity of 88.00%. The AUC of liver cancer group was 0.919, the sensitivity was 85.00% and the specificity was 88.00%. Conclusion Serum Hcy in patients with gastrointestinal cancer increased significantly, the Hcy as a tumor marker for the diagnosis of gastrointestinal tumors, especially for the diagnosis of liver cancer has some clinical value.