论文部分内容阅读
目的分析家族性结直肠腺瘤性息肉病(FAP)癌变的危险因素。方法选取医院2013年10月-2016年10月收治的FAP癌变患者42例设为癌变组,选取同期收治的FAP无癌变患者40例设为非癌变组,回顾性分析2组患者临床资料,分析FAP癌变的危险因素。结果 FAP癌变危险因素主要为发病年龄、腺瘤大小、肿瘤数量、有FAP家族史、腺瘤组织学、有肠外表现(合并胃、十二指肠息肉、脂肪瘤及小肠息肉等)及癌胚抗原水平增高等;行定期内镜下息肉切除术占25.6%,外科手术治疗占74.4%。结论结直肠FAP癌变倾向高,且危险因素较多,临床需尽早诊断与治疗,定期筛查患者家系成员,以改善预后。
Objective To analyze the risk factors of carcinogenesis of familial colorectal adenomatous polyposis (FAP). Methods Forty-two patients with FAP cancers from October 2013 to October 2016 in our hospital were enrolled as the cancerous patients. Forty FAP cancerous patients treated in the same period were enrolled as non-cancerous patients. The clinical data of two groups were analyzed retrospectively Risk factors for FAP carcinogenesis. Results The main risk factors of FAP were age of onset, size of adenoma, number of tumor, family history of FAP, histology of adenoma, extraintestinal manifestations (combined stomach, duodenal polyp, lipoma and small intestine polyp) and cancer The level of embryo antigen increased; the routine endoscopic polypectomy accounted for 25.6%, surgical treatment accounted for 74.4%. Conclusions Colorectal FAP has a high tendency of carcinogenesis and many risk factors. Clinic should be diagnosed and treated as soon as possible, and family members of patients should be screened regularly to improve the prognosis.