大黄蛰虫丸源于汉·张仲景《金匮要略》 ,其功能祛瘀生新、缓中补虚 ,主治内有干血、肌肤甲错、两目黯黑的淤血内阻症。文献报告本药的醇提取物有显著的抑制血小板聚集和体内、外血栓形成的药理作用。本文观察了药物对纤溶酶原活性、全血还原比粘度的影响 ,探讨了大黄蛰虫丸活 The rhubarb locust pill is derived from Han Zhangzhongjing’s “Golden Chamber”, and its function is new and moderate tonic. There are dry blood, skin awkward, and dark internal congestion in the attending person. The literature reports that the alcohol extracts of the drug have significant pharmacological effects in inhibiting platelet aggregation and in vivo and in vitro thrombosis. This article observed the effect of drugs on the activity of plasminogen and reduction ratio of whole blood, and discussed the activity of rhubarb locust pills.