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目的:探讨不同强度的噪声对高血压患者肾素活性(PRA)和醛固酮(ALD)的影响。方法:选取从事与噪声相关职业的高血压患者1150例作为研究对象,检测其接触不同强度噪声后血浆PRA和ALD水平。结果:在接触噪声强度<80 dB的高血压患者中,实验前及实验6、12个月后PRA和ALD浓度比较,差异均无统计学意义(P>0.05);在接触噪声强度>80dB的高血压患者中,实验12个月后PRA和ALD浓度均较实验前明显升高(P<0.05);相同噪声干预高血压患者,12个月后基础血压越高,PRA和ALD的水平也越高(P<0.05)。结论:80dB强度的噪声的干预使高血压患者血浆中PRA和ALD水平升高,而且PRA和ALD的上升水平可能与基础血压水平有关
Objective: To investigate the effects of different intensities of noise on renin activity (PRA) and aldosterone (ALD) in patients with essential hypertension. Methods: A total of 1150 hypertensive patients engaged in noise-related occupations were enrolled in this study. Plasma PRA and ALD levels were measured after exposure to different intensities of noise. Results: There were no significant differences in PRA and ALD concentrations between prehypertensive and experimental groups (P> 0.05) in patients with hypertension who were exposed to noise level <80 dB. There was no significant difference between the two groups (P> 0.05) The levels of PRA and ALD in hypertensive patients after 12 months of experiment were significantly higher than those before the experiment (P <0.05). After the same noise intervention in hypertensive patients, basal blood pressure was higher after 12 months and the levels of PRA and ALD were also higher High (P <0.05). CONCLUSIONS: An 80-dB noise intervention increases the plasma PRA and ALD levels in patients with essential hypertension and the elevated PRA and ALD levels may be related to baseline blood pressure levels