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目的 探讨老年人反流性食管炎 (RE)的相关危险因素和临床特点。 方法 观察 113例老年RE患者的吸烟史、饮酒史、非甾体类抗炎药物 (NSAID)、钙离子拮抗剂 (CCB)和硝酸甘油类 (NGs)药物服用史及幽门螺杆菌(HP)感染状态 ,同时记录酸反流、烧心、胸骨后灼痛和呼吸道症状 (如咳嗽、喘鸣等 )。 结果 老年RE组吸烟、饮酒、服用NSAID、CCB、NGs分别占 2 4 8%、2 3 9%、10 6%、16 8%、9 7% ,而非老年RE组则分别为 17 2 %、13 8%、3 4%、8 6%、6 8% ,2组有显著差异 (P <0 0 5 ) ;老年RE组HP感染率为 34 % ,非老年RE组HP感染率为 5 2 6% (P <0 0 5 ) ;老年RE组酸反流、呼吸道症状分别占 67 3%和 5 4 9% ,而非老年RE组分别为 47 7%和 2 5 % (P <0 0 5和P <0 0 1) ,烧心和胸骨后灼痛发生率老年组为 41 6%和 2 8 3% ,而非老年RE组分别为 70 4%和 5 6 8% ,2组有显著差异(P <0 0 1)。 结论 老年人饮酒、吸烟、服用NSAID、CCB、NGs是RE发生的相关危险因素 ;其临床症状老年人以酸反流和呼吸道症状为常见 ,而烧心、胸骨后灼痛相对少见 ;HP感染在老年人可能减少RE的发生
Objective To investigate the risk factors and clinical features of reflux esophagitis (RE) in the elderly. Methods The smoking history, drinking history, non-steroidal anti-inflammatory drugs (NSAIDs), calcium ion antagonists (CCBs) and nitroglycerin (NGs) drug taking history and HP infection of 113 elderly patients with RE were observed. State, while recording acid reflux, heartburn, burning after the sternum and respiratory symptoms (such as cough, wheezing, etc.). Results The smoking, drinking, taking NSAID, CCB and NGs in aged RE group were respectively 24.8%, 23.9%, 106%, 168% and 97%, while those in non-elderly RE group were 17.2% 13 8%, 34%, 86% and 68% respectively. There was a significant difference between the two groups (P <0.05). HP infection rate was 34% in elderly RE group and 526 in non-elderly RE group %, Respectively (P <0.05). The reflux reflux and respiratory symptoms of elderly RE patients accounted for 67.3% and 54.9% respectively, while those in non-elderly RE patients were 47.7% and 25% respectively (P <0.05 and P <0.05) P <0.01). The incidence of heartburn and post-sternal burn was 41.6% and 28.3% in the elderly group compared with 70.4% and 56.8% in the non-elderly RE group, respectively <0 0 1). Conclusion Elderly people drinking alcohol, smoking, taking NSAID, CCB and NGs are the related risk factors of RE. The clinical symptoms are common in the elderly with acid reflux and respiratory symptoms, while heartburn and post-sternal burn are relatively rare. People may reduce the occurrence of RE