If离子流是心脏起搏电流的重要组成部分,超极化激活的环核苷酸门控通道 (hyperpolerization activatedcyclicnucleotid gatedchannels,HCN通道)和野生型If离子通道有相似的分子生物学结构和通道动力学特征。对HCN通道的研究成为从分子水平深入探讨心脏起搏机制的重要内容。目前有关HCN通道的研究已取得了一些进展,但其在心脏起搏中的作用机制仍不清楚。 If ion flux is an important part of cardiac pacing current, hyperpolerization-activated cyclic nucleotide gated channels (HCN channels) and wild-type If ion channels have similar molecular biology and channel kinetics feature. The study of HCN channels has become an important part of the study of cardiac pacing mechanism at the molecular level. At present, some progress has been made in the study of HCN channels, but its mechanism of action in cardiac pacing is still not clear.