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为了探讨肠易激综合征（IrritablebowelsyndromeIBS）患者胃肠激素及一氧化氮（NO）的变化，以及它们可能的作用和临床意义。方法：采用放免等方法测定了IBS患者乙状结肠粘膜内血管活性肠肽（VIP）、生长抑素（SS）、P物质（SP）、胃动素（MTL）和一氧化氮合成酶（NOS）的含量。结果：VIP在IBS便秘组显著高于正常人与IBS腹泻组（P＜0．01）；SP在IBS腹泻组显著高于正常人和IBS便秘组（P＜0.01）；SS在IBS各组均显著高于正常人（P＜0.01～0．05）；S在IBS各组均显著高于正常人（P＜0．01～0．05），而便秘组又显著高于腹泻组（P＜0．01）；MTL在腹泻组显著高于正常人（P＜0．01），而在便秘组显著低于正常人（P＜0．01）；NOS在IBS便秘组显著高于正常人和IBS腹泻组（P＜0.01）。结论：IBS患者存在着VIP、SS、SP和MTL的含量和NOS的活性异常，并且这些异常在IBS的发病中起着重要作用；不同类型的IBS其胃肠激素和NO含量有显著差异，说明不同类型患者在发病机理上有其不同的病理生理学基础。
In order to investigate the changes of gastrointestinal hormones and nitric oxide (NO) in patients with irritable bowel syndrome (IBS) and their possible roles and clinical significance. Methods: The levels of vasoactive intestinal peptide (VIP), somatostatin (SS), substance P (SP), motilin (MTL) and nitric oxide synthase (NOS) in patients with IBS were measured by radioimmunoassay content. Results: VIP in IBS constipation group was significantly higher than that in normal individuals and IBS diarrhea group (P <0.01); SP was significantly higher in IBS diarrhea group than in normal people and IBS constipation group (P <0.01) (P <0.01 ~ 0.05). S was significantly higher in all IBS groups than in normal controls (P <0.01 ~ 0.05), while the constipation group was significantly higher than that of diarrhea group (P < 0.01). MTL in diarrhea group was significantly higher than that in normal people (P <0.01), but lower in constipation group than in normal people (P <0.01) IBS diarrhea group (P <0.01). Conclusions: There are VIP, SS, SP and MTL contents and NOS activity abnormalities in IBS patients, and these abnormalities play an important role in the pathogenesis of IBS; different types of IBS have significant differences in gastrointestinal hormone and NO content, indicating Different types of patients have different pathophysiological basis on the pathogenesis.