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目的:分析多囊卵巢综合征(PCOS)患者子宫内膜不典型增生的药物转化疗效及安全性。方法:回顾性分析17例PCOS子宫内膜不典型增生患者,其中9例曾用孕激素治疗未转化者为A组;8例未曾治疗者为B组,均检测口服葡萄糖耐量试验(OGTT)并同时行胰岛素释放试验,以检测患者是否存在胰岛素抵抗(IR)及高胰岛素血症。17例患者均采用口服避孕药联合二甲双胍治疗。结果:17例PCOS患者均存在IR及高胰岛素血症,经药物治疗3~6个周期后,内膜不典型病变均成功转化。结论:采用口服避孕药联合二甲双胍治疗PCOS合并IR的子宫内膜不典型增生患者是一种临床上实用、有效的治疗方法。
Objective: To analyze the efficacy and safety of drug conversion in endometrial dysplasia of patients with polycystic ovary syndrome (PCOS). Methods: A retrospective analysis of 17 cases of PCOS endometrial dysplasia patients, of which 9 cases had been treated with progesterone unconverted group A; 8 cases of untreated group B, were measured oral glucose tolerance test (OGTT) and At the same time, insulin release test to detect whether the patient’s insulin resistance (IR) and hyperinsulinemia. 17 patients were treated with oral contraceptives combined with metformin. Results: 17 cases of PCOS patients were both IR and hyperinsulinemia, after 3 to 6 cycles of drug treatment, atypical lesions were successfully transformed. Conclusion: Oral contraceptives combined with metformin in patients with endometrial dysplasia and PCOS complicated with IR is a clinically practical and effective treatment.