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重组DNA等先进研究方法的建立和发展对毒理遗传学产生了巨大影响。目前已能分离单个突变基因,进行结构与功能的详尽分析;确定基因在正常及异常个体中染色体上的位置,深入了解染色体的结构与功能;利用限制性片段长度多态性(RFLP)及其他实验系统迅速地查出单碱基或微小突变的存在并正确地判断突变的性质及位置;重组DNA技术已开始用于癌形成机理的研究以及环境毒物的快速检测;此外,计算机等先进技术也已进入对诱变、致癌剂分子结构分析及环境物质遗传毒性预言等领域。
The establishment and development of advanced research methods such as recombinant DNA have had a tremendous impact on toxicological genetics. It is now possible to isolate a single mutant gene for detailed analysis of its structure and function, to determine the location of the gene on chromosomes in both normal and abnormal individuals, to gain insight into the structure and function of the chromosomes, to use restriction fragment length polymorphisms (RFLPs) and others The experimental system quickly detects the presence of a single base or small mutation and correctly determines the nature and location of the mutation; recombinant DNA technology has begun to be used for the study of cancer formation mechanisms and for the rapid detection of environmental toxicants; in addition, advanced technologies such as computers Has entered the mutagenesis, molecular structure analysis of carcinogens and environmental substances, such as genetic toxicity prediction.