目的:探讨抗菌药物合理使用对多重耐药菌感染发生率的影响。方法:采用干预措施,观察和探讨合理使用抗菌药物对多重耐药菌感染发生率的影响。结果:经治疗,干预组患者多重耐药菌感染发生率为0.95%,明显低于对照组的2.57%,比较差异有统计学意义(P<0.05)。结论:合理使用抗菌药物可有效降低多重耐药菌感染的发生率,值得临床推广应用。 Objective: To investigate the rational use of antimicrobial agents on the incidence of multi-drug resistant bacteria infection. Methods: Interventions were used to observe and explore the impact of rational use of antibacterials on the incidence of multiple drug-resistant bacterial infections. Results: After treatment, the incidence of multi-drug resistant bacterial infection in the intervention group was 0.95%, which was significantly lower than that in the control group (2.57%, P <0.05). Conclusion: The rational use of antimicrobial agents can effectively reduce the incidence of multiple drug-resistant bacterial infections, worthy of clinical application.