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siRNA能高效且特异地阻断内源性同源基因的表达即RNA干涉(RNAi).RNAi在临床中的应用需要开发安全有效的输送系统,脂质纳米输送载体是一种具有发展潜力的siRNA输送系统.siRNA-脂质复合物的形成主要通过静电相互作用,静电作用必须足够强以至于载体在运输过程中不释放siRNA,而载体到达治疗部位时,解聚释放出siRNA.载体的粒径应小于100 nm,以利于细胞的摄取和透过特定部位的血管开窗.为了减少网状内皮系统(RES)的摄取和延长载体的循环时间,载体的表面由聚乙二醇修饰.本文主要综述了构建siRNA输送载体的基本要求.
siRNA can efficiently and specifically block the expression of endogenous homologous genes, RNA interference (RNAi). The clinical application of RNAi needs to develop a safe and effective delivery system, and the lipid nano-delivery vector is a promising siRNA Delivery system.siRNA-lipid complexes are formed primarily through electrostatic interactions that must be strong enough that the carrier does not release siRNA during transport and the carrier depolymerizes to release siRNA when it reaches the site of treatment.The particle size of the carrier Should be less than 100 nm in order to facilitate cellular uptake and window opening through blood vessels at specific sites.In order to reduce the uptake of the reticuloendothelial system (RES) and prolong the circulation time of the carrier, the surface of the carrier is modified by polyethylene glycol. The basic requirements for constructing siRNA delivery vectors are reviewed.