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目的探讨前入路肝切除术在原发性肝癌（肝癌）手术中的应用价值。方法回顾性分析2011年6月至2014年6月中山大学孙逸仙纪念医院和中山大学附属第三医院岭南医院收治138例行肝癌肝切除患者临床资料。其中男97例，女41例；年龄36～87岁，中位年龄52岁。所有患者均签署知情同意书，符合医学伦理学规定。根据不同手术方式将患者分为前入路肝切除组（前入路组，63例）和传统入路肝切除组（传统组，75例）。两组患者术前一般资料及术中、术后各项指标比较采用t检验或χ2检验。结果前入路组肝功能Child-Pugh分级B、C级、多发肿瘤、肿瘤直径>10 cm患者分别占73%（46/63）、44%（28/63）、16%（16/63），明显高于传统组的37%（28/75）、17%（13/75）、5%（4/75）（χ2=20.444，12.051，8.144；P<0.05）。前入路组平均术中出血量、输血浆量、输红细胞量分别为（428±17）、（470±14）、（300±7）ml，明显低于传统组的（517±11）、（630±15）、（420±11）ml（t=-6.097，-2.927，-8.928；P<0.05）；前入路组切除术后并发症发生率10%（6/63）明显低于传统组的17%（13/75）（χ2=1.759，P10 cm was 73%(46/63), 44%(28/63) and 16%(16/63) respectively, which were signiifcantly higher compared with 37%(28/75), 17%(13/75) and 5%(4/75) in the traditional group (χ2=20.444, 12.051, 8.144;P<0.05). In the anterior group, the average intraoperative blood loss, transfusion volume of plasma and red blood cells were (428±17), (470±14) and (300±7) ml, which were signiifcantly lower compared with (517±11), (630±15) and (420±11) ml in the traditional group (t=-6.097,-2.927,-8.928;P<0.05). The rate of postoperative complications in anterior group was 10%(6/63), which was signiifcantly lower compared with 17%(13/75) in the traditional group (χ2=1.759, P<0.05). Conclusion For patients with poor liver function, multiple and large tumors, hepatectomy via anterior approach is a preferential surgical procedure rather than the traditional approach hepatectomy.