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目的：比较脂必妥与多烯康的降脂疗效。方法：脂必妥组７４例（男性４９例，女性２５例；年龄５６±ｓ８ａ）给脂必妥３片（０．３５ｇ／片），ｐｏ，ｔｉｄ×８ｗｋ；多烯康组３６例（男性２５例，女性１６例；年龄５５±８ａ）给多烯康胶丸４粒（０．４５ｇ／粒），ｐｏ，ｔｉｄ×８ｗｋ。结果：脂必妥治疗后ＴＣ，ＴＧ，ＬＤＬ－ｃｈ和ＡｐｏＢ１００下降极显著（Ｐ＜０．０１）。ＨＤＬ－ｃｈ和ＨＤＬ－ｃｈ／ＴＣ比值显著升高（Ｐ＜０．０５，Ｐ＜０．０１）。而对照组治疗后ＴＣ无显著下降（Ｐ＞０．０５），ＨＤＬ－ｃｈ亦无显著升高（Ｐ＞０．０５）。但组间对比ＨＤＬ－ｃｈ及ＨＤＬ－ｃｈ／ＴＣ比例２组升幅差异均不显著（Ｐ＞０．０５）。脂必妥用于２７例高尿酸血症治疗８ｗｋ后血清尿酸显著下降（Ｐ＜０．０１）。２组均无严重副作用。结论：调脂作用，脂必妥优于多烯康。
OBJECTIVE: To compare the lipid-lowering effects of lipidbide and doetilon. Methods: Seventy-six patients (49 males and 25 females; age 56 ± s8a) were given lipostilrate (0.35g / tablet), po, tid × 8wk 25 cases, 16 females; age 55 ± 8a) to give 4 tablets of polyene gum (0.45g / tablets), po, tid × 8wk. Results: The decrease of TC, TG, LDL-ch and ApoB100 was significant (P <0.01) after treatment with Lipid. HDL-ch and HDL-ch / TC ratio was significantly increased (P <0.05, P <0.01). However, no significant decrease in TC was found in the control group (P> 0.05), HDL-ch was also not significantly increased (P> 0.05). However, there was no significant difference between the two groups in the HDL-ch and HDL-ch / TC ratios (P> 0.05). Serum uric acid was decreased significantly (P <0.01) after the application of Lipid in 27 cases of hyperuricemia for 8 weeks. There were no serious side effects in both groups. Conclusion: Lipid-regulating effect is better than doemectin.