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目的研究非小细胞肺癌(NSCLC)骨转移发生骨相关事件(SREs)的风险因素及其对患者预后的影响。方法回顾性研究2010~2012年该院223例NSCLC骨转移患者的临床特征,用单因素分析和多因素分析对SREs的预测因素分析。结果223例NSCLC骨转移患者中,发生SREs患者为119例(53.4%)。单因素分析显示女性、无吸烟史、腺癌、单发骨转移病灶患者发生SREs风险低于男性、吸烟史、非腺癌、多发骨转移病灶患者,差异有统计学意义(P<0.05),其余各项差异无统计学意义(P>0.05)。多因素分析显示多发骨转移是发生SREs的独立风险因素。NSCLC骨转移患者的中位生存时间为15.3个月,生存分析显示NSCLC骨转移患者发生SREs对预后无显著影响(P>0.05)。结论 NSCLC骨转移患者中,女性、腺癌、不吸烟史、单发骨转移病灶患者发生SREs风险更低,多发骨转移是发生SREs的独立风险因素,应注意监测和预防。
Objective To study the risk factors of bone related events (SREs) in bone metastasis of non-small cell lung cancer (NSCLC) and its effect on the prognosis of patients. Methods The clinical features of 223 NSCLC patients with bone metastases from 2010 to 2012 were retrospectively analyzed. Predictors of SREs were analyzed by univariate and multivariate analysis. Results Of the 223 NSCLC patients with bone metastases, 119 (53.4%) had SREs. Univariate analysis showed that the incidence of SREs in women with no history of smoking, adenocarcinoma and single bone metastases was significantly lower than that in men, smoking history, non-adenocarcinoma and multiple bone metastases (P <0.05) The remaining differences were not statistically significant (P> 0.05). Multivariate analysis showed that multiple bone metastasis was an independent risk factor for SREs. The median survival time of patients with NSCLC bone metastasis was 15.3 months. Survival analysis showed no significant effect of SREs on the prognosis in patients with NSCLC bone metastasis (P> 0.05). Conclusions In NSCLC patients with bone metastases, the incidence of SREs is lower in women with adenocarcinoma, non-smoking history and single bone metastasis, and multiple bone metastasis is an independent risk factor for SREs. Therefore, monitoring and prevention should be paid attention to.