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三叉神经脊束核尾侧亚核浅层（I、II层）内有较密集的谷氨酸样、γ-氨基丁酸样和甘氨酸样阳性终未。这些终未除分别来自外周初级传入或局部神经元外，还可能来自脑干的核团。为了探讨这些阳性终未的脑干起源部位，本研究用荧光金逆行追踪与免疫荧光组织化学染色相结合的双标技术对三叉尾侧亚核浅层内谷氨酸能、γ-氨基丁酸能和甘氨酸能终未在脑干的起源部位进行了追踪。结果表明：大鼠脑干向三叉尾侧亚核发出谷氨酸能、γ-氨基丁酸能和甘氨酸能投射的神经元主要位于构成下行抑制系统的中脑中央灰质、中缝大核及其周围的网状结构、中缝苍白核和中缝隐核。本研究的结果提示，除已知的5-羟色胺和P物质外，谷氨酸、γ-氨基丁酸和甘氨酸也可能参与下行抑制系统，对面口部伤害性刺激信息传递发挥调控作用。
Trigeminal nerve bundle caudal subnucleus superficial (I, II layer) with more dense glutamate-like, γ-aminobutyric acid-like and glycine-like positive end. These eventually did not come from the peripheral primary afferent or regional neurons, but also from the brainstem nuclei. In order to explore these positive terminal sites of brain stem origin, the study of fluorescent gold retrograde tracing and immunofluorescence histochemical staining of double-labeled technology on the trisomy caudal sub-nuclear glutamate, γ-aminobutyric acid Can and glycine can not be traced in the brain stem of the origin. The results showed that the brainstem of rat brainstem emitted glutamate energy to the trigeminal caudal nucleus, and the neurons that could be projected by γ-aminobutyric acid and glycine were mainly located in central mesencephalon, Mesh structure, pale stitches and syndesmotic. The results of this study suggest that glutamate, gamma-aminobutyric acid and glycine, besides the known serotonin and substance P, may also participate in the down-regulation system and play a regulatory role in the information transmission of noxious stimulation of oral mouth.