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阿朴吗啡是一种已知的拟多巴胺药物,能使人和大鼠血清催乳素的水平下降.但因这种作用消失快;严重地限制在临床上作为催乳素减少剂的使用.本文所报道的阿朴吗啡双,三甲基乙酰酯(ADPE),是阿朴吗啡的一种双酯前体药,能产生长效的对多巴胺能神经递质的阿朴吗啡作用和中枢生化作用,显示对雄性大鼠催乳素活性的长久抑制.实验使用体重200～220g雄性Wistar大鼠.每笼放置三只,每日保持14小时光照和10小时黑暗.实验前要求大鼠在恒温(22±2℃)和恒温(60%)下至少喂养十天.
Apomorphine is a known dopodamine drug that decreases the level of serum prolactin in humans and rats, but disappears quickly due to this effect; it severely limits its clinical use as a prolactin reducer. The reported apomorphine bis- and trimethylacetoacetate (ADPE), a diester prodrug of apomorphine, produces long-lasting apomorphine effects and central biochemical effects on dopaminergic neurotransmitters, Showing long-term inhibition of prolactin activity in male rats.Experiments using male Wistar rats weighing 200-220 g were placed in three cages per cage for 14 hours of light and 10 hours of darkness before the experiment required rats at a constant temperature (22 2 ° C) and isothermal (60%) for at least 10 days.