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目的：观察HFRS沙鼠肾灭活疫苗（Ⅰ型）加强免疫后的血清学效果及防病效果。方法：采用间接免疫荧光试验和双夹心ELISA法，检测血清中的IgG抗体；以微量细胞病变中和试验，检测血清中的中和抗体。结果：加强免疫前，血清抗体阳性率仅为18．3％，中和抗体阳性率为0％；加强免疫后2周，抗体阳性率升至90.1％，中和抗体阳性率达75％。加强免疫后1年内，接种组无1例病人发生，而未接种者发病5例。
Objective: To observe the serological and anti-pathogenic effects of HFRS nephrotoxicity inactivated vaccine (type Ⅰ). Methods: Indirect immunofluorescence assay and double sandwich ELISA were used to detect IgG in serum. Neutralization antibody in serum was detected by neutralization test with trace amount of cytopathic effect. Results: Before boosting, the positive rate of serum antibody was only 18.3% and the positive rate of neutralizing antibody was 0%. The positive rate of antibody increased to 90.1% and the positive rate of neutralizing antibody reached 75% 2 weeks after boosting. Within one year after booster immunization, there was no one patient in the vaccinated group, and five in the non-vaccinated group.