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目的探讨内美通(孕三烯酮)联合米非司酮治疗子宫内膜异位症(内异症)的临床疗效及副反应。方法内异症患者作为观察对象。用药方法为月经来潮第2天开始服孕三烯酮,每周2次,2.5mg/次。司米安10mg或米非司酮12.5mg,1次/d,连服12周为1个疗程。同时加服保肝药物。用药前后作性激素测定。结果经1～2个疗程治疗后,临床症状完全消失,月经都被控制,且阴道无不规则性流血。46例中完全缓解31例,占67.39%(其中有2例已妊娠4个月);部分缓解7例,占15.21%;轻度缓解6例,占13.04%;无效2例,占4.34%。总有效率为95.66%。无肝功能损害和性激素变化,仅有少数患者体质量增高。结论孕三烯酮联合小剂量司米安治疗内异症的疗效确切。从初步治疗结果分析,本方案具有一定的推广应用价值。
Objective To investigate the clinical efficacy and side effects of enamel (gestrinone) combined with mifepristone in the treatment of endometriosis (endometriosis). Methods Endometriosis patients as observation object. Medication method for the first two days of menstrual cramps to start serving gestrinone, 2 times a week, 2.5mg / time. Simmian 10mg or mifepristone 12.5mg, 1 time / d, even for 12 weeks for a course of treatment. At the same time add clothes liver medicine. Sex hormone test before and after treatment. Results 1 to 2 courses of treatment, the clinical symptoms disappeared completely, menstruation was controlled, and the vagina without irregular bleeding. Among the 46 cases, 31 cases were completely relieved, accounting for 67.39% (2 of them were 4 months pregnant); 7 cases were partial remission (15.21%); 6 cases were mild remission (13.04%); 2 cases were ineffective (4.34%). The total effective rate was 95.66%. No liver damage and sex hormone changes, only a small number of patients with increased body mass. Conclusions Gestrinone combined with low dose of semifestine is effective in treating endometriosis. Analysis of the results from the initial treatment, the program has some promotion and application value.