他汀类药物治疗能够显著降低卒中发生率和减轻缺血性脑损伤,通过多种不同的机制发挥神经保护作用,包括稳定动脉粥样硬化斑块、改善内皮功能、减轻炎症反应和再灌注损伤。另外,他汀类药物还能通过阻止β-淀粉样蛋白形成和减少载脂蛋白E分泌而减少痴呆的发生。 Statin therapy can significantly reduce the incidence of stroke and reduce ischemic brain damage through a variety of mechanisms to exert neuroprotective effects, including stabilizing atherosclerotic plaque, improving endothelial function, reducing inflammation and reperfusion injury. In addition, statins also reduce dementia by preventing beta-amyloid formation and decreasing apolipoprotein E secretion.