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文献报告治疗高血压病的大多数β-阻滞剂可并发肢体变冷和雷诺氏现象,对高血压伴有末梢血管性缺陷的患者还报告有发生末梢皮肤坏疽。作者报告3例高血压病患者,分别用β-阻滞剂:心得安(propranolol),心得平(oxprenolol)或氯酰心安(atenolol)治疗,用药后均在冬季发生足部严重疼痛,而后又出现趾、蹠多发性小片皮肤坏死,但足部脉搏均可触知。这些表现在停药一月左右都恢复正常。所有患者都不吸烟,β-阻滞药剂量都在许可范围,患者也无末梢血管性疾患。足部脉搏可以触知可与发生坏疽的病例相区别。所有3例的症状都发生在冬季,说明与小血管有关,其发生机理不明,可
Most beta-blockers reported in the literature for the treatment of hypertension are associated with cold limbs and Raynaud’s phenomenon, and peripheral skin gangrene is also reported in patients with hypertension and peripheral vascular defects. The authors report that 3 patients with essential hypertension were treated with beta-blockers propranolol, oxprenolol, or atenolol, respectively, and severe foot pain occurred in winter after treatment Toe, plantar multiple small pieces of skin necrosis, but the foot pulse can be palpable. These manifestations returned to normal after about one month of withdrawal. All patients did not smoke, β-block dose are within the allowable range, patients also have no peripheral vascular disease. Foot pulse can be palpable with the occurrence of gangrene cases are different. All three cases of symptoms occurred in winter, indicating that the small blood vessels, the mechanism of its occurrence is unknown, but