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目的探讨2型糖尿病肾病大鼠胰岛素抵抗与足细胞减少的关系。方法选取40只Wistar大鼠随机分为2组(对照组和糖尿病肾病组),观察各组大鼠血糖、血胰岛素、24 h尿微量白蛋白及足细胞的动态变化。结果 2型糖尿病肾病大鼠胰岛素抵抗与足细胞减少呈正相关。结论胰岛素抵抗在2型糖尿病肾病发病及足细胞减少过程中起一定的作用。
Objective To investigate the relationship between insulin resistance and podocyte in type 2 diabetic nephropathy rats. Methods Forty Wistar rats were randomly divided into two groups (control group and diabetic nephropathy group). The changes of blood glucose, blood insulin, 24h urine microalbumin and podocyte were observed. Results There was a positive correlation between insulin resistance and podocyte reduction in type 2 diabetic nephropathy rats. Conclusion Insulin resistance plays a role in the pathogenesis of type 2 diabetic nephropathy and podocyte reduction.