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目的:探讨异体输血对消化道出血患者凝血功能血小板及部分免疫功能的影响。方法:选择消化性溃疡出血患者40例,血红蛋白65~75g/L,其中对照组患者20例,不给予输血治疗,试验组患者20例,给予输注少白红细胞2~4U,并分别于输血前、输血后1d抽取2组患者静脉血,检测患者凝血功能及外周血中自然杀伤细胞(NK)、IgG、IgA、IgM、CD3~+、CD4~+、CD8~+、CD4~+/CD8~+的变化情况。结果:输血后1d试验组患者,NK细胞、CD3~+、CD4~+、CD4~+/CD8~+较输血前显著减少(P<0.05);输血后1d,试验组患者IgG减少,差异有统计学意义(P<0.05),2组IgA、IgM变化不显著(P>0.05);输血前、输血后1d2组患者凝血功能及血小板指标变化均差异不显著(P>0.05)。结论:异体输血对纠正患者失血性贫血有疗效,但对患者免疫功能抑制明显;对于异体输血量在一定范围内的患者凝血功能无明显影响。
Objective: To investigate the effects of allogeneic blood transfusion on platelets and some immune functions in patients with gastrointestinal hemorrhage. Methods: 40 patients with peptic ulcer bleeding, 65 ~ 75g / L hemoglobin, including 20 patients in the control group, not given blood transfusions, 20 patients in the test group, given white blood cells transfusion 2 ~ 4U, and were transfused Blood samples were obtained from venous blood before and 1 day after blood transfusion to detect coagulation function and peripheral blood NK, IgG, IgA, IgM, CD3 +, CD4 +, CD8 +, CD4 + / CD8 ~ + Changes. Results: The levels of NK cells, CD3 +, CD4 +, CD4 + / CD8 + in the test group decreased significantly compared with that before transfusion (P <0.05) (P <0.05). There was no significant difference in IgA and IgM between the two groups (P> 0.05). Before transfusion, there was no significant difference in coagulation function and platelet index between the 1d2 group and the 1d2 group after transfusion (P> 0.05). CONCLUSION: Allogeneic blood transfusion is effective in correcting hemorrhagic anemia in patients, but it has obvious effect on immune function. There is no significant effect on blood coagulation in patients with allogeneic transfusion volume.