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目的:检测Ⅰ型子宫内膜样腺癌中胰岛素样生长因子1受体(insulin-like growth factor-1 receptor,IGF-1R)和IGF-2R蛋白的表达情况,探讨M6P/IGF-2R在Ⅰ型子宫内膜样腺癌中的作用。方法:采用免疫组织化学PV法检测正常增生期子宫内膜(对照组)20例、Ⅰ型子宫内膜样腺癌(腺癌组)30例组织中IGF-1R和IGF-2R的表达情况。结果:IGF-1R在Ⅰ型子宫内膜样腺癌中过阳性表达,高于在正常子宫内膜组织中的表达(P=0.006)。IGF-2R在Ⅰ型子宫内膜样腺癌中的总阳性表达与过阳性表达,均低于正常子宫内膜组织(P值分别为0.043和0.000)。结论:IGF-2R阳性表达的下调以及IGF-1R的异常高表达在Ⅰ型子宫内膜样腺癌的发生和发展过程中可能具有重要作用。
Objective: To detect the expression of IGF-1R and IGF-2R in type Ⅰ endometrial adenocarcinoma and to explore the role of M6P / IGF-2R in type Ⅰ Type endometrioid adenocarcinoma of the role. Methods: Immunohistochemical PV method was used to detect the expression of IGF-1R and IGF-2R in 20 cases of normal proliferative endometrium (control group) and 30 cases of type Ⅰ endometrial adenocarcinoma (adenocarcinoma group). Results: IGF-1R was overexpressed in type I endometrioid adenocarcinoma and higher than in normal endometrium (P = 0.006). The total positive expression and over-expression of IGF-2R in type I endometrioid adenocarcinoma were lower than that in normal endometrial tissue (P values were 0.043 and 0.000 respectively). Conclusion: The down-regulation of IGF-2R expression and the abnormally high expression of IGF-1R may play an important role in the development and progression of type Ⅰ endometrial adenocarcinoma.