传统认为骨肉瘤有肺转移患者的预后很差。但1971年Martini氏选择了22例骨肉瘤孤立肺转移病人作了积极的外科手术,其中45%存活了36个月,27%存活五年以上。如以化疗配合,疗效当更提高。本文报告45个骨肉瘤肺转移的儿童患者,用连续化疗包括高剂量氨甲喋呤(HDMTX)加甲酰四氢叶酸钙解 Traditionally, osteosarcoma has a poor prognosis in patients with lung metastases. In 1971, Martini chose active surgical procedures for 22 cases of isolated lung metastases of osteosarcoma, of which 45% survived for 36 months and 27% survived for more than 5 years. If combined with chemotherapy, the efficacy is even higher. This article reports 45 children with osteosarcoma lung metastases treated with continuous chemotherapy including high-dose methotrexate (HDMTX) plus calcium folinate