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JM 是来自人胸腺不成熟 T 细胞的急性淋巴细胞白血病细胞系.本文以 SAC 刺激的人外周血纯化 B 淋巴细胞和小鼠脾细胞增殖为模型,观察了 JM 细胞培养上清(SPN_(JM))对人 B 淋巴细胞和小鼠脾细胞增殖的免疫调节作用.发现具有 T 细胞抑制活性的 SPN_(JM)对人和小鼠 B 淋巴细胞的增殖具有促进作用。在无 SAC 诱导时,SPN_(JM)与 HrIL—2协同对 B 细胞仍有促增殖作用.本实验还发现,高浓度时对 T 细胞具有抑制作用的 SPN_(JM),在低浓度时(1:640)对 T 细胞增殖亦具有促进作用.
JM is an acute lymphoblastic leukemia cell line derived from human thymus immature T cells.In this study, SAC-stimulated proliferation of human peripheral blood mononuclear cells and mouse splenocytes was used as a model to investigate the effects of SPN_ (JM) ) On the proliferation of human B lymphocytes and mouse splenocytes.It was found that SPN JM with T cell suppressive activity promoted the proliferation of human and mouse B lymphocytes. In the absence of SAC induction, synergistic effect of SPN_ (JM) and HrIL-2 on proliferation of B cells was also observed.At the same time, SPN_ (JM) inhibited T cells at high concentration : 640) on T cell proliferation also has a promoting effect.