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目的 研究迷走神经刺激术治疗难治性癫痫的适应证选择、手术方法、术后程控及疗效.方法 2009年11月~2016年7月清华大学玉泉医院癫痫中心对25例难治性癫痫患者行迷走神经刺激术,术后给予程控管理控制癫痫发作;并通过随访回顾性分析术后疗效.结果 术后随访患者4个月~7年,其中癫痫发作频率减少达McHughⅠ级6例、Ⅱ级12例、Ⅲ级4例、Ⅳ级1例、Ⅴ级2例.手术前后癫痫发作频率对比,差异有统计学意义(P<0.05).结论 迷走神经刺激术作为一种安全有效的辅助治疗难治性癫痫的方法,其治疗效果可以随着参数的调整和时间延长而增强,并可以一定程度改善患者的认知行为和生活质量.“,”Objective To explore the curative effects of vagus nerve stimulation ( VNS ) on intractable epilepsy .Methods The clinical data of 25 patients with intractable epilepsy , who were treated by VNS in our center from November 2009 to July 2016, were analyzed retrospectively . Results The follow up from 4 months to7 years showed that of 25 patients, 6(24%) belonged in MCHugh grade Ⅰ, 12(48%) in gradeⅡ, 4(16%) in gradeⅢand 3(12%) in grades Ⅳ~Ⅴ. Conclusions VNS is a safe and effective method to treat the intractable epilepsy .VNS may make seizure frequency reduce over 50% in more than 60% patients with intractable epilepsy .The present results suggested that the curative effect is correlated with the stimulation parameter and duration.